RESEARCH ARTICLE


Effects of Thyroid Dysfunction on Lipid Profile



C.V Rizos, M.S Elisaf, E.N Liberopoulos*
Department of Internal Medicine, School of Medicine, University of Ioannina, Ioannina, Greece


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© Rizos et al.; Licensee Bentham Open.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the Department of Internal Medicine, Medical School, University of Ioannina, Ioannina 45110, Greece; Tel: +30-26510-07502; Fax: +30-26510-07016; E-mail: vaglimp@yahooo.com


Abstract

Thyroid dysfunction has a great impact on lipids as well as a number of other cardiovascular risk factors. Hypothyroidism is relatively common and is associated with an unfavorable effect on lipids. Substitution therapy is beneficial for patients with overt hypothyroidism, improving lipid profile. However, whether subclinical hypothyroidism should be treated or not is a matter of debate. On the other hand, hyperthyroidism can be associated with acquired hypocholesterolemia or unexplained improvement of lipid profile. Overall, thyroid dysfunction should be taken into account when evaluating and treating dyslipidemic patients.

Keywords: Cardiovascular disease, dyslipidemia, hypothyroidism, hyperthyroidism, lipoprotein (a), thyroid autoimmunity, thyroid dysfunction, thyroxine treatment..