Effect of Intermittent Versus Continuous Parathyroid Hormone in the Cardiovascular System of Rats

Smajilovic, Sanela; Schaal-Jensen, Rasmus; Jabbari, Reza; Smajilovic, Una; Haunso, Stig; Tfelt-Hansen, Jacob

Effect of Intermittent Versus Continuous Parathyroid Hormone in the Cardiovascular System of Rats

Sanela Smajilovic³, Rasmus Schaal-Jensen^{1, 2}, Reza Jabbari^{1, 2}, Una Smajilovic¹, Stig Haunso^{1, 2}, Jacob Tfelt-Hansen^{1, 2, *}

¹ Laboratory of Molecular Cardiology, Department of Cardiology, Copenhagen University Hospital, Rigshospitalet, Denmark

² The Danish National Research Foundation Centre for Cardiac Arrhythmia (DARC), Copenhagen

³ Department of Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Denmark

Article Information

Identifiers and Pagination:

Year: 2010
Volume: 4
First Page: 110
Last Page: 116
Publisher ID: TOCMJ-4-110
DOI: 10.2174/1874192401004010110

Article History:

Received Date: 25/2/2010
Revision Received Date: 8/3/2010
Acceptance Date: 10/3/2010
Electronic publication date: 31/3/2010
Collection year: 2010

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© Smajilovic et al.; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

^* Address correspondence to this author at the Laboratory of Molecular Cardiology, Copenhagen University Hospital, section 9312, Juliane Mariesvej 20 2100 Copenhagen Ø Denmark; Tel: +45 35456506/61360399; Fax: +45 35456500; E-mail: tfelt@dadlnet.dk

Objective:

PTH increases ionic calcium concentration in the serum, acting primarily on bone and kidney cells through the type 1 PTH receptor. Interestingly, PTH stimulates bone formation when administrated intermittently but causes severe bone loss with continuous administration. Daily injections of PTH are used as the most promising anabolic agent in the treatment of severe osteoporosis. Elevated PTH is reported an independent risk factor for left ventricle hypertrophy.

Design:

in rats we investigated the effect of intermittent and continuous administration of PTH on blood pressure, heart rate and development of cardiac hypertrophy and fibrosis.

Results:

We did not find PTH to induce heart hypertrophy. In contrast, continuous administration of PTH the mRNA level of a hypertrophic marker gene, atrial natriuretic peptide. When comparing the effect of continuously versus injected PTH collagen 1 mRNA was significantly higher in continuously treated animals.

Conclusion:

our data demonstrated a decrease in heart rate upon continuous administration of PTH in rats. No changes in blood pressure were observed. Moreover, neither intermittent nor continuous administration of PTH induced ventricular hypertrophy. But continuous PTH induced a marker of collagen 1. Thus, these data did not reveal any negative effects of the injection of PTH on the cardiovascular system.

Keywords: PTH, continuous, intermittently..

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RESEARCH ARTICLE

Effect of Intermittent Versus Continuous Parathyroid Hormone in the Cardiovascular System of Rats

Article Information

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Abstract

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Design:

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Conclusion:

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