RESEARCH ARTICLE


Effect of Hemodialysis, Coronary Artery Disease and Diabetes on Cardiac Troponin T: A Prospective Survey Over One Year



François-Pierre Mongeon1, #, Marc Dorais1, Jacques Le Lorier1, 2, Daniel Froment2, Élaine Letendre2, Stéphane Rinfret3, #, *
1 Centre Hospitalier de l’Université de Montréal (CHUM) Research Centre
2 Centre Hospitalier de l’Université de Montréal (CHUM), Montreal, Canada
3 Clinical Clinical and Interventional Cardiology, Multidisciplinary cardiology department, Laval Hospital, Quebec Heart and Lung Institute, 2725, chemin Sainte-Foy, Quebec(Quebec) Canada, G1V 4G5

Article Information


Identifiers and Pagination:

Year: 2009
Volume: 3
First Page: 69
Last Page: 77
Publisher ID: TOCMJ-3-69
DOI: 10.2174/1874192400903010069

Article History:

Received Date: 4/5/2009
Revision Received Date: 11/5/2009
Acceptance Date: 13/5/2009
Electronic publication date: 24/6/2009
Collection year: 2009

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Creative Commons License
© Mongeon et al.; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the Multidisciplinary Cardiology Department, Institut de Cardiologie et de Pneumologie de Québec, 2725, chemin Sainte-Foy, Quebec (Quebec) Canada, G1V 4G5; Tel: 418-656- 8711; Fax: 418-656-4544; E-mail: stephane.rinfret@criucpq.ulaval.ca
# At the time this study was performed, these authors were affiliated with the Centre Hospitalier de l’Université de Montréal (CHUM)


Abstract

Background:

Limited data is available about the effects of hemodialysis sessions, coronary artery disease (CAD), and diabetes on serum cardiac troponin T (cTnT) levels in patients with end-stage renal disease (ESRD).

Objectives:

To test whether hemodialysis could be associated with an increase in cTnT concentration. To evaluate if coronary artery disease (CAD) or diabetes are associated with higher cTnT levels in ESRD.

Methods:

Serum cTnT levels were measured immediately before and after dialysis 3 times over 1 year (0, 6, and 12 months).

Results:

A total of 100 ESRD patients without acute coronary syndrome (mean age of 58.5 years, 34% with diabetes, and 37% with CAD) gave 267 pre-dialysis and 260 post-dialysis blood samples. The mean (standard deviation) pre-dialysis cTnT levels were 0.06 (0.12), 0.05 (0.06), and 0.07 (0.07) mcg/L at 0, 6, and 12 months, respectively. The post-dialysis cTnT levels were similar on average. Among 259 samples with cTnT measured both before and after dialysis, 79 (30.5%) showed a decrease in serum cTnT, 97 (37.5%) showed an increase and 83 (32%) showed no change following dialysis. Mean cTnT was higher in CAD than in non-CAD patients. We observed no significant difference in mean cTnT levels between diabetic and non-diabetic patients.

Conclusions:

cTnT levels were not affected by individual hemodialysis sessions, and remained stable around 0.06 mcg/L over a 1-year period in ESRD patients. Random cTnT levels were higher in stable CAD patients undergoing hemodialysis.

Key Words: Coronary artery disease, diabetes mellitus, kidney, troponin T..