Aorta Remodeling Responses to Distinct Atherogenic Stimuli: Hyperten-sion, Hypercholesterolemia and Turbulent Flow/Low Wall Shear Stress
Cibele M Prado, Marcos A Rossi*
Identifiers and Pagination:Year: 2008
First Page: 41
Last Page: 48
Publisher ID: TOCMJ-2-41
Article History:Received Date: 12/5/2008
Revision Received Date: 28/5/2008
Acceptance Date: 2/6/2008
Electronic publication date: 13/6/2008
Collection year: 2008
open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/), which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited.
This review is based on recently published data from our laboratory. We investigated the role of hypertension and laminar flow, hypercholesterolemia and laminar flow and turbulent blood flow/low wall shear stress, and turbulent blood flow/low wall shear stress associated with hypercholesterolemia on aorta remodeling of rats feeding normal diet or hypercholesterolemic diet. Our findings suggest that increased circumferential wall tension due to hypertension plays a key role in the remodeling through biomechanical effects on oxidative stress and increased TGF-β expression; the remodeling observed in the presence of hypercholesterolemia could be initiated by oxidative stress that is involved in several processes of atherogenesis and this remodeling is more pronounced in the presence of turbulent blood flow/low wall shear stress.