RESEARCH ARTICLE


Aorta Remodeling Responses to Distinct Atherogenic Stimuli: Hyperten-sion, Hypercholesterolemia and Turbulent Flow/Low Wall Shear Stress



Cibele M Prado, Marcos A Rossi*
Department of Pathology, Faculty of Medicine of Ribeirão Preto, University of São Paulo, S.P., Brazil


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© Prado and Rossi et al.; Licensee Bentham Open

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/), which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited.

* Address correspondence to this author at the Department of Pathology, Faculty of Medicine of Ribeirão Preto, University of São Paulo, 14049-900 Ribeirão Preto, SP, Brazil; Tel/Fax: +55 16 3602 3130; E-mail: marossi@fmrp.usp.br


Abstract

This review is based on recently published data from our laboratory. We investigated the role of hypertension and laminar flow, hypercholesterolemia and laminar flow and turbulent blood flow/low wall shear stress, and turbulent blood flow/low wall shear stress associated with hypercholesterolemia on aorta remodeling of rats feeding normal diet or hypercholesterolemic diet. Our findings suggest that increased circumferential wall tension due to hypertension plays a key role in the remodeling through biomechanical effects on oxidative stress and increased TGF-β expression; the remodeling observed in the presence of hypercholesterolemia could be initiated by oxidative stress that is involved in several processes of atherogenesis and this remodeling is more pronounced in the presence of turbulent blood flow/low wall shear stress.