Nitric Oxide and Related Aspects Underlying Angina

Carolina Baraldi Araujo Restini*, Leticia Gonçalves
Biotechnology Dept. (Lab: Cardiorenal Pharmacology)/Medical School, University of Ribeirao Preto (UNAERP), Ribeirão Preto-SP, Brazil

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Creative Commons License
© 2017 Restini and Gonçalves.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Biotechnology Dept Cardiorenal Pharmacology)/Medical School, University of Ribeirao Preto (UNAERP), Avenida Costabile Romano 2201, 14096 – 900. Ribeirão Preto-SP, Brazil; Tel: +55-16-3603-6795; Fax: +55-16-3603-6795; E-mails:;


Increased number of patients affected by metabolic syndrome (MS) has prompted the necessity of better understanding what is involved in such syndrome. Nevertheless, the establishment of promising therapies depends on the knowledge about the interaction of molecules within MS. In such context, Nitric Oxide (NO) emerges from a bulk of works relating its roles on aspects of MS, including cardiovascular diseases, their symptoms and comorbidities, which are thought to be triggered by similar sources. NO, nitric oxide synthase and enzymatic chains are keys for those disease and symptoms processes. NO has been separately described as part of hypertensive, ischemic and pain signaling. Although there are similar pathways likely shared for generating cardiovascular symptoms such angina, they are barely associated to NO in literature. The present review aims to clarify the patterns of NO alteration in metabolic syndrome directly concerned to cardiovascular symptoms, especially angina.

Keywords: Angina, Cardiovascular symptoms, Cell signaling, Nitrergic nerves, Nitric Oxide, Nitric Oxide Synthase, Pain.