Nitric Oxide and Related Aspects Underlying Angina

The Open Cardiovascular Medicine Journal 17 Apr 2017 REVIEW ARTICLE DOI: 10.2174/1874192401711010033


Increased number of patients affected by metabolic syndrome (MS) has prompted the necessity of better understanding what is involved in such syndrome. Nevertheless, the establishment of promising therapies depends on the knowledge about the interaction of molecules within MS. In such context, Nitric Oxide (NO) emerges from a bulk of works relating its roles on aspects of MS, including cardiovascular diseases, their symptoms and comorbidities, which are thought to be triggered by similar sources. NO, nitric oxide synthase and enzymatic chains are keys for those disease and symptoms processes. NO has been separately described as part of hypertensive, ischemic and pain signaling. Although there are similar pathways likely shared for generating cardiovascular symptoms such angina, they are barely associated to NO in literature. The present review aims to clarify the patterns of NO alteration in metabolic syndrome directly concerned to cardiovascular symptoms, especially angina.

Keywords: Angina, Cardiovascular symptoms, Cell signaling, Nitrergic nerves, Nitric Oxide, Nitric Oxide Synthase, Pain.
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