Impact of 3 Common ABCA1 Gene Polymorphisms on Optimal vs Non-Optimal Lipid Profile in Greek Young Nurses



Apostolia Marvaki 1, 2, Vana Kolovou 1, Niki Katsiki 3, Maria Boutsikou 2, Anastasia Kotanidou 4, Stylianos Orfanos 5, Gerasimos Filippatos 6, Katerina Marvaki 7, Anastasios Koumoulidis 8, Sophie Mavrogeni 2, Genovefa Kolovou *, 2
1 Molecular Immunology Laboratory
2 Onassis Cardiac Surgery Center Athens, Greece
3 2nd Propedeutic Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, Hippocration Hospital, Thessaloniki, Greece
4 1stDepartment of Critical Care Medicine and Pulmonary Services, Medical School of Athens, Greece
5 2ndDepartment of Critical Care Medicine, Medical School of Athens, Greece
6 2ndDepartment of Cardiology, Medical School of Athens, Greece
7 General Hospital, Katerini, Greece
8 Department of Cardiology, Evangelismos Hospital, Athens, Greece


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© Marvaki et al.; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the Onassis Cardiac Surgery Center, 356 Sygrou Ave 176 74 Athens, Greece; Tel: +30 210 9493520; Fax: +30 210 9493336; E-mail: genovefa@kolovou.com


Abstract

Objective:

This study is in line with two previous ones from our group. They evaluated the influence of ATP-binding cassette transporter A1 (ABCA1) gene polymorphisms [such as rs2230806 (R219K), rs2230808 (R1587K) and rs4149313 (I883M)] on the human lipid profile (defined as Optimal and Non-Optimal).

Methods:

The present study included 447 unrelated young women and men self-reported as being healthy and that attended the University of Nursing of Technological and Educational Institution. All subjects were genotyped and the ABCA1 polymorphisms (R219K, R1587K and I883M) were recorded. According to lipid profile [total cholesterol, triglyceride, high-density lipoprotein cholesterol and low-density lipoprotein cholesterol (LDL-C)] the subjects were separated into those with optimal lipid profile (Optimal Group, n=209) and Non-Optimal Group (n=238).

Results:

No statistical differences were observed in the distribution of R219K, R1587K and I883M polymorphisms according to the lipid profile (p>0.05 in all cases). No statistical differences were observed in the distribution of R219K, R1587K and I883M polymorphisms according to sex (p>0.05 in all cases). However, Logistic Regression revealed that subjects with RK (R1587K polymorphism) genotype had 69% increased risk on average of having LDL-C above normal limits as compared with those with RR genotype. Similarly, subjects with K allele (R1587K polymorphism) had 59% increased risk on average of having LDL-C above normal limits compared with those with R allele.

Conclusion:

These findings suggest that R1587K polymorphism of ABCA1 gene may influence the lipid profile. However, this needs to be confirmed by larger studies.

Keywords: ATP-binding cassette transporter A1 gene, high-density lipoprotein cholesterol, lipid profile, low-density lipoprotein cholesterol, polymorphisms, triglycerides..