Tumor Encasement of the Right Coronary Artery: Role of Anatomic and Functional Imaging in Diagnosis and Therapeutic Management

INTRODUCTION

Despite the limited current reports of tumor encasement of a coronary artery, coronary encasement can be a life-threatening condition [1-4] In this work we present two rare cases of right coronary artery (RCA) involvement by a mediastinal tumor.

CASE PRESENTATIONS

Case 1

The first case is a 55-year-old woman with mild chest discomfort over several years due to a long-standing history of B3 thymoma. The patient underwent complete tumor resection followed by radiotherapy 12 years ago. She had a tumor recurrence with mediastinal and pericardial invasion and metastasis to both lungs and left subclavian node 7 years ago and she received radical anterior mediastinal resection, as well as resection of the pericardial metastases followed by chemotherapy and radiotherapy. A drug eluting stent was implanted in the RCA due to an incidental injury of the vessel during resection of the pericardial metastasis.

Non-gated multi-detector coronary computed tomo-graphy angiography (MDCTA) was performed which visualized the thymoma in the anterior mediastinum, involving the middle and distal RCA (Fig. 1, Panels A-E). Despite the tumor encasement, the RCA remained patent (Fig. 1, Panels A-E). Fluoroscopic coronary angiography was subsequently performed to further confirm the patencyof RCA (Fig. 1, Panel F). The patient underwent a debulking surgery to remove as much of the mass as possible while avoiding injuring the RCA. She recovered uneventfully from the surgery and was discharged home with a recommendation of regular follow-up.

DISCUSSION

In this report we presented two rare cases of a mediastinal tumor encasing the RCA. Different degrees and locations of RCA involvement were noted. The treatment approach varied from conservative to surgical. The first case was a known recurrent thymoma involving the proximal and distal RCA without compromising vessel’s patency. The tumor was treated with debulking surgery. Thymoma is a most common anterior mediastnal tumors in adults, but with rare involvement of the heart [5]. It can manifest with myasthenia gravis, compression or encasing of adjacent structures, pleural seedings and paraneoplastic syndromes [6]. The second case was a poorly differentiated mediastinal tumor with encasement of the entire RCA with patency only of its proximal segment. The tumor was treated conservatively due to patient’s preference.

The RCA entrapment into a mediastinal tumor has been described as the floating artery sign. This sign has been reported to be specific for diffuse large B cell lymphoma [1, 2], but our case demonstrated that thymoma can also demonstrate similar image findings. Diffuse large B cell lymphomas have been reported to frequently encase coronary arteries in the right sided atrioventricular groove [1, 7]. Other types of malignancies, such as angiosarcoma, were shown to cause coronary artery invasion with subsequent pseudoaneurysm or intracoronary thrombus formation [3]. CT is the imaging modality of choice to diagnose, guide therapy and follow-up mediastinal tumors. FDG PET/CT should also be considered, as happened with the second case, especially in case of poorly differentiated tumors.

To the best of our knowledge, there is no evidence-based consensus regarding the treatment of mediastinal tumors encasing coronary arteries. As for the treatment of recurrent thymoma, surgery can improve survival for cases with local recurrence or if complete excision is possible [6]. When complete excision cannot be achieved, like with our first patient, debulking surgery can be considered which, however, has questionable results regarding patient outcomes [6]. Adjuvant radiotherapy and chemotherapy can be also beneficial when radical resection cannot be achieved due to close proximity of the tumor to important vessels or in case of aggressive tumors (B2 or B3) [6, 8].

CONCLUSION

In summary, we demonstrated two cases of RCA involvement by a mediastinal tumor with different degrees and locations of RCA involvements followed by different treatment approaches. RCA entrapment into a mediastinal tumor can manifest as the floating artery sign or with subsequent pseudoaneurysm or intracoronary thrombus formation secondary to intraluminal invasion from more aggressive tumors. Diffuse large B cell lymphomas frequently manifest coronary encasement in the right atrioventricular groove. Coronary artery involvement by mediastinal tumors is important to be investigated with imaging as it may guide the surgical planning. Complete surgical excision can improve survival for cases of recurrent thymomas, and adjuvant radiotherapy and chemotherapy can be also beneficial when radical resection cannot be achieved.

REFERENCES