RESEARCH ARTICLE


Prevalence, Characteristics, and In-Hospital Outcomes of Metabolic Syndrome among Patients with Acute Coronary Syndrome in the United Arab Emirates



Abdulla Shehab1, #, *, Bayan Al-Dabbagh1, #, Wael Almahmeed2, Nazar Bustani2, Nicolaas Nagelkerke3, Abdulla Alnaeemi4, Alawi A Alsheikh-Ali2, 5
1 Department of Internal Medicine, Faculty of Medicine and Health Sciences, United Arab Emirates University, United Arab Emirates
2 Heart and Vascular Institute, Sheikh Khalifa Medical City, Abu Dhabi, United Arab Emirates
3 Department of Community Medicine, Faculty of Medicine and Health Sciences, United Arab Emirates University, Unit-ed Arab Emirates
4 Zayed Military Hospital, Abu Dhabi, United Arab Emirates
5 Tufts Clinical and Translational Science Institute, Tufts Medical Center, Boston, MA, USA


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© Shehab et al.; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the Department of Internal Medicine, Faculty of Medicine & Health Sciences, PO Box 17666, UAE University, Al Ain, UAE; Tel: + 9713-7137491; Fax: + 9713-7672995; E-mail: a.shehab@uaeu.ac.ae
# these authors contributed equally to this work.


Abstract

Objective:

To evaluate clinical profiles, management and in-hospital outcomes of acute coronary syndrome (ACS) patients with metabolic syndrome (MetS) in the United Arab Emirates (UAE).

Methods:

MetS was defined according to the criteria for its diagnosis by the International Diabetes Federation (IDF) and the American Heart Association/National Heart, Lung and Blood Institute (AHA/NHLBI). Participants were admitted to various hospitals in the UAE with a diagnosis of ACS in 2007 as part of the Gulf Registry of Acute Coronary Events (Gulf RACE) project. We compared baseline characteristics, treatment patterns, and in-hospital outcomes stratified by MetS status.

Results:

Of 1259 patients with ACS in the UAE (mean age: 52 ± 11 years, 88.8% males), the majority (n = 851, 67.6%) had MetS. MetS patients were more frequently males (86.4 vs 13.6%; P < 0.001). They were more obese (waist circumference and BMI, P < 0.001) as compared with non-MetS patients. MetS was more frequently associated with hypertension (51.1 vs 37.7%; P < 0.001) and diabetes mellitus (45.6 vs 24.3%; P < 0.001). After multivariate adjustment, certain MetS criteria rather than MetS itself were associated with higher in-hospital mortality and heart failure. Paradoxically, hypertension was associated with lower in-hospital mortality.

Conclusions:

Prevalence of MetS among patients with ACS in our study population was high. Certain MetS criteria were associated with higher in-hospital mortality and heart failure.

Keywords: acute coronary syndrome, Gulf Registry of Acute Coronary Events, metabolic syndrome, Middle East, obesity, United Arab Emirates..