RESEARCH ARTICLE


A Novel Expression of Exercise Induced Pulmonary Hypertension in Human Immunodeficiency Virus Patients: A Pilot Study



Rami Doukky 1, 3, *, Won Y Lee 2, Mahindhar Ravilla 3, Omar B Lateef 4, Victor Pelaez 3, Audrey French 5, Rajive Tandon 4
1 Rush University Medical Center, Department of Medicine, Section of Cardiology, 1653 W. Congress Pkwy, Jelke 1015, Chicago, IL 60612, USA
2 University of Texas Southwestern Medical Center, Department of Medicine, Division of Pulmonary and Critical Care Medicine, 5939 Harry Hines Blvd, Dallas, TX 75390, USA
3 John H. Stroger, Jr. Hospital of Cook County, Department of Medicine, Division of Adult Cardiology, 1901 W. Harrison Street, Chicago, IL 60612, USA
4 Rush University Medical Center, Department of Medicine, Division of Pulmonary and Critical Care Medicine, 1750 W. Harrison Street, Jelke 297, Chicago, IL 60612, USA
5 John H. Stroger, Jr. Hospital of Cook County, Department of Medicine, Division of Infectious Diseases, 1900 W. Polk Street, Chicago, IL 60612, USA


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© Doukky et al.; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the Rush University Medical Center, Section of Cardiology, 1653 W. Congress Pkwy, Chicago, IL 60612, Tel: 312-563-2534; Fax: 312-942-6334; E-mail: rami_doukky@rush.edu


Abstract

Background:

Patients with the human immunodeficiency virus (HIV) are at risk for multiple pulmonary complications including pulmonary hypertension. Exercise induced pulmonary hypertension (EIPH) has been previously described in patients with scleroderma, sickle cell disease and chronic obstructive pulmonary disease, yet has not been associated with the HIV population.

Methods:

A prospective case-control study design was implemented. Four HIV patients with unexplained dyspnea and four healthy controls underwent symptom-limited stationary bicycle exercise. Transthoracic Doppler Echocardiography was used to measure tricuspid regurgitation velocity which was used to calculate the right ventricular to right atrial pressure (RV-RA) gradient at rest and at peak exercise using the simplified Bernoulli’s equation. Change in RV-RA gradient between rest and peak exercise was calculated and considered to represent change in pulmonary arterial systolic pressure.

Results:

The mean age was 41.25 years (±8.7) for patients and 33.5 years (±6.0) for controls. The mean CD4 count of patients was 191.5 cells/μL (±136.2). Patients had a significantly higher increase in RV-RA gradient as compared to controls (180.2% vs. 27.5%, p = 0.03).

Discussion:

This pilot study suggests that it is feasible to use recumbent bicycle and transthoracic Doppler echocardiography for the evaluation of EIPH among HIV patients with dyspnea of unknown etiology. The study is too small to draw any broad conclusion. Further evaluation of this concept with a larger study is warranted.

Keywords: Human immunodeficiency virus (HIV), pulmonary hypertension, exercises induced pulmonary hypertension..