RESEARCH ARTICLE


Dyslipidemia Associated with Chronic Kidney Disease



Vasilis Tsimihodimos, Zoi Mitrogianni, Moses Elisaf*
Department of Internal Medicine, Medical School, University of Ioannina, Ioannina, Greece


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© Tsimihodimos et al.; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the Department of Internal Medicine, Medical School, University of Ioannina, 45110 Ioannina, Greece; Tel: +30-2651-0-07509; Fax: +30-2651-0-07016; E-mail: egepi@cc.uoi.gr


Abstract

Cardiovascular disease is a major cause of morbidity and mortality in patients with impaired renal function. Dyslipidemia has been established as a well-known traditional risk factor for cardiovascular disease (CVD) in the general population and it is well known that patients with chronic kidney disease (CKD) exhibit significant alterations in lipoprotein metabolism. In this review, the pathogenesis and treatment of CKD-induced dyslipidemia are discussed. Studies on lipid abnormalities in predialysis, hemodialysis and peritoneal dialysis patients are analyzed. In addition, the results of the studies that tested the effects of the hypolipidemic drugs on cardiovascular morbidity and mortality in patients with CKD are reported.

Keywords: Chronic kidney disease, renal failure, dyslipidemia, hypertriglyceridemia, hemodialysis, peritoneal dialysis..