RESEARCH ARTICLE


Malignancy-Associated Dyslipidemia



Agata Bielecka-Dąbrowa1, Simon Hannam2, Jacek Rysz3, Maciej Banach1, *
1 Department of Hypertension, Medical University of Lodz, Poland
2 Department of Child Health, King's College London School of Medicine, London, UK
3 Deprtament of Nephrology, Hypertension and Family Medicine, Medical University of Lodz, Poland


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© Bielecka-Dąbrowa et al.; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the Department of Hypertension, Medical University of Lodz, Poland, Zeromskiego 113; 90-549 Lodz, Poland; Tel: +48 42 639 37 50; Fax: +48 42 639 37 50; E-mail: maciejbanach@aol.co.uk


Abstract

Cholesterol and triglycerides, important lipid constituents of cell, are essential to carry out several vital physiological functions. Lipids might be associated with cancers because they play a key role in the maintenance of cell integrity. The pathway for cholesterol synthesis may also produce various tumorigenic compounds and cholesterol serves as a precursor for the synthesis of many sex hormones linked to increased risk of various cancers. In some malignant diseases, blood cholesterol undergoes early and significant changes. The mechanism for the link between cancer and cholesterol remains controversial. The dates from studies are confusing because both hypolipidemia and hypercholesterolemia might be connected with malignancy. Not only cancers but also antineoplastic therapies have an influence on lipid profile. There are also dates suggesting that antihyperlipemic drugs might nfluenced malignancy.

Keywords: Cancer, dyslipidemia, cholesterol, statins..