Coronary Artery Disease in an Asymptomatic Population Undergoing a Multidetector Computed Tomography (MDCT) Coronary Angiography
Ghassan Zaid1, Dana Yehudai1, Uri Rosenschein1, Abdel-Rauf Zeina2, 3, *
Identifiers and Pagination:Year: 2010
First Page: 7
Last Page: 13
Publisher Id: TOCMJ-4-7
Article History:Received Date: 29/12/2009
Revision Received Date: 8/1/2010
Acceptance Date: 12/1/2010
Electronic publication date: 29/1/2010
Collection year: 2010
open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited.
To assess the prevalence of coronary artery disease (CAD) in asymptomatic subjects using multidetector computed tomography (MDCT) and its relationships to demographic and clinical risk factors.
Material and method:
We enrolled consecutive asymptomatic volunteers with no evidence of ischemic heart disease that underwent MDCT for the early detection of CAD. All MDCT findings were correlated with demographic and risk factors. A total of 2820 coro-nary segments were analyzed in 188 asymptomatic subjects (150 males and 38 females), aged 54.4 ± 7.4 years.
A total of 128 (68%) demonstrated MDCT findings compatible with CAD; of these 111 (86.7%) had non-significant (diameter stenosis ≤ 50%) and 17 (13.3%) had significant CAD (diameter stenosis ≥ 50%). Compared with older subjects (mean age 56±8 years), younger subjects had a lower prevalence of MDCT findings of CAD 55.5% vs. 12.5%, respectively (P<0.001), regardless of risk factors. Males had more CAD (mostly non-significant) compared with females (109 [72.7%] vs. 19 [50.3%], respectively; P= 0.007). Subjects with ≥ 2 risk factors had a higher prevalence of CAD in general and significant CAD in particular (P<0.001).
CAD in asymptomatic population seems to be not uncommon. Using MDCT a high prevalence of non-significant and low prevalence of significant CAD was discovered in middle age asymptomatic population.