The Effect of Passive Opium Smoking on Cardiovascular Indices of Rabbits with Normal and Ischemic Hearts

Joukar, Siyavash; Najafipour, Hamid; Malekpour-Afshar, Reza; Mirzaeipour, Fatemeh; Nasri, Hamid Reza

The Effect of Passive Opium Smoking on Cardiovascular Indices of Rabbits with Normal and Ischemic Hearts

Siyavash Joukar^{1, *}, Hamid Najafipour², Reza Malekpour-Afshar³, Fatemeh Mirzaeipour⁴, Hamid Reza Nasri⁴

¹ Department of Physiology and Physiology Research Center

² Department of Physiology, Physiology Research Center and neuroscience Research Center

³ Department of Pathology and neuroscience Research Center

⁴ Department of Cardiology and Physiology Research center; Kerman University of Medical Sciences, Kerman, Iran

Article Information

Identifiers and Pagination:

Year: 2010
Volume: 4
First Page: 1
Last Page: 6
Publisher ID: TOCMJ-4-1
DOI: 10.2174/1874192401004010001

Article History:

Received Date: 10/11/2009
Revision Received Date: 19/11/2009
Acceptance Date: 24/11/2009
Electronic publication date: 5/1/2010
Collection year: 2010

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© Joukar et al.; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

^* Address correspondence to this author at the Department of Physiology and Physiology Research Center, Kerman University of Medical Sciences, Medical Faculty, Bulvd. 22 Bahman, Postal Code 7616914111, Kerman, Iran; Tel: +98 341 3220081; Fax: +98 341 3220081; E-mails: Jokar@kmu.ac.ir, sjokar@gmail.com

Some Asian people believe that opium can protect the cardiovascular system. To assess this belief, we investigated the effect of passive opium smoking (POS) on cardiovascular indices in rabbits with ischemic and non-ischemic hearts.

Rabbits (n = 43) were divided into control (CTL), short term opium (SO) and long term opium (LO) groups. SO and LO groups were exposed to opium smoking for 3 days and 4 weeks, respectively. ECG, blood pressure (BP), left ventricular pressure and cardiac troponin I levels were recorded. Isoproterenol (ISO) was injected to induce cardiac ischemia and after 4 h the above variables were measured along with cardiac histopathology assessment.

All groups showed significant increments in troponin I level (P < 0.05) except the CTL group. This trend was more obvious in ISO-treated groups. Mean arterial pressure (MAP) significantly decreased in all groups (p< 0.05) except the LO group. Opium exposure attenuated ISO-induced myodegeneration but augmented tissue congestion and hemorrhage.

In conclusion, higher troponin I serum level and ECG changes were found in passive opium smoking groups. This evidence is against the belief that opium can protect the cardiovascular system.

Keywords: Opium smoking, cardiac ischemia, cardiac troponin I, histopathology..

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RESEARCH ARTICLE

The Effect of Passive Opium Smoking on Cardiovascular Indices of Rabbits with Normal and Ischemic Hearts

Article Information

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Abstract

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