Animal Models of Cardiac Disease and Stem Cell Therapy

Lailiang Ou1, 2, #, Wenzhong Li2, #, *, Yi Liu1, #, Yue Zhang2, #, Shen Jie2, 3, #, Deling Kong1, Gustav Steinhoff2, Nan Ma2, 4
1 Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Science, Nankai University, Tianjin, China
2 Reference- and Translation Center for Cardiac Stem Cell Therapy (RTC), Department of Cardiac Surgery, University of Rostock, Rostock, Germany
3 The First Central Hospital of Tianjin, Tianjin Medical University, Tianjin, China
4 Institute of Polymer Research, GKSS Forschung4szentrum, Teltow, Germany

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© Ou et al.; Licensee Bentham Open.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution License ( which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited.

* Address correspondence to this author at the Department of Cardiac Surgery, University Rostock, Schillingallee 69, 18057 Rostock, Germany; Tel: +49-381-494 6215; Fax: +49-381-494 6214; E-mail:
# These authors contributed equally.


Animal models that mimic cardiovascular diseases are indispensable tools for understanding the mechanisms underlying the diseases at the cellular and molecular level. This review focuses on various methods in preclinical research to create small animal models of cardiac diseases, such as myocardial infarction, dilated cardiomyopathy, heart failure, myocarditis and cardiac hypertrophy, and the related stem cell treatment for these diseases.

Keywords: Animal model, myocardial infarction, dilated cardiomyopathy, heart failure, myocarditis, cardiac hypertrophy, stem cell..