RESEARCH ARTICLE


Experimental Models of Abdominal Aortic Aneurysms



Janice C Tsui*
Division of Surgery & Interventional Science, University College London, Royal Free Campus, Pond Street, London NW3 2QG, UK


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© Janice C. Tsui; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the Division of Surgery & Interventional Science, University College London, Royal Free Campus, Pond Street, London NW3 2QG, UK; Tel: (+44) 207 794 0500 ext 33938; Fax: (+44) 2074726278; E-mail: j.tsui@medsch.ucl.ac.uk


Abstract

Despite being a leading cause of death in the West, the pathophysiology of abdominal aortic aneurysms (AAA) is still incompletely understood. Pharmacotherapy to reduce the growth of small AAAs is limited and techniques for repairing aneurysms continue to evolve. Experimental models play a key role in AAA research, as they allow a detailed evaluation of the pathogenesis of disease progression. This review focuses on in vivo experimental models, which have improved our understanding of the potential mechanisms of AAA development and contributed to the advancement of new treatments.

Keywords: Abdominal aortic aneurysms (AAA), experimental models, elastase infusion. .