RESEARCH ARTICLE
Oxidative Stress As A Common Mediator for Apoptosis Induced-Cardiac Damage in Diabetic Rats
Mohammad M Dallak1, Dimitri P Mikhailidis2, *, Mohamed A Haidara1, Ismaeel M Bin-Jaliah1, Olaa M Tork3, Moshira A Rateb3, Hanaa Z Yassin3, Zeinb A Al-refaie3, Ibrahim M Ibrahim3, Samy M Elawa4, Laila A Rashed5, Noha A Afifi6
Article Information
Identifiers and Pagination:
Year: 2008Volume: 2
First Page: 70
Last Page: 78
Publisher ID: TOCMJ-2-70
DOI: 10.2174/1874192400802010070
Article History:
Received Date: 30/6/2008Revision Received Date: 9/7/2008
Acceptance Date: 16/7/2008
Electronic publication date: 7/8/2008
Collection year: 2008

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/),which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited
Abstract
Abstract:Aim:
To investigate the possible role of oxidative stress as a common mediator of apoptosis and cardiac damage in diabetes.
Materials and Methods:
This experimental work was conducted on 5 groups of Wistar rats. Group I was the control group. Diabetes type 1 was induced in other groups (by streptozotocin) and animals received insulin or vitamin E (300 mg /kg body weight), both insulin and vitamin E, or no treatment for 4 weeks according to their group. At the end of the study, serum and cardiac tissues were examined for biochemical parameters of cardiac function, oxidative stress and apoptosis. Electron microscopy pictures of cardiac tissue were also evaluated for signs of cardiac damage
Results:
Markers of oxidative stress, apoptosis, inflammation as well as manifestations of cardiac damage as assessed by electron microscopy were significantly decreased in rats treated with both insulin and vitamin E when compared with untreated diabetic rats or rats treated with either insulin or vitamin E alone
Conclusion:
Administration of both vitamin E and insulin was effective in reducing markers of oxidative stress and apoptosis and improving parameters of cardiac function in experiments animals. Antioxidants might prove beneficial as an adjuvant treatment in addition to insulin in type 1 diabetes associated with manifestations of cardiac complications