RESEARCH ARTICLE


Quantitative Doppler-Echocardiographic Determination of Regurgitant Volume in Patients with Aortic Insufficiency



Paul Schoenhagen*, a, Ludwig Drudeb, Hermann H Kleinc, Mario J Garciaa
a From the The Cleveland Clinic Foundation, Cleveland, Ohio, USA
b Kardiologische Gemeinschaftspraxis Marburg, Germany
c Klinikum Idar-Oberstein GmbH, Germany


2008 Bentham Science Publishers Ltd.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/), which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited.

* Address correspondence to this author at the Cleveland Clinic Foundation, Hb-6, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA; Tel: (216) 444-7579; Fax: (216) 445-1492; E-mail: schoenp1@ccf.org


Abstract

Background:

The severity of aortic regurgitation (AR) can be determined by invasive or echocardiographic methods. We systematically compared quantitative invasive and echocardiographic data with semiquantitative invasive grades in a prospective series of patients.

Methods:

Using Doppler-echocardiography we determined the cardiac output over the aortic, pulmonary and mitral valve in 27 patients (20 with, 7 without AR). Aortic regurgitant volume was calculated as the difference between the cardiac output over aortic and pulmonary valve/ mitral valve. During angiography the severity of AR was assessed semiquantitatively by aortography and the regurgitant volume was calculated invasively as the difference between the left- and right ventricular cardiac output.

Results:

The echocardiographically and invasively determined regurgitant blood volume correlated closely (R≈0.8). The regurgitant volume increased with higher angiographic grade but there was significant overlap between adjoining qualitative grades.

Conclusion:

In patients with AR, quantitative echocardiographic and angiographic measurements of the regurgitant volume correlate closely.

Keywords: Aortic Insufficiency, Doppler-Echocardiography, Cardiac Catheterization, Regurgitant Volume..