Evidence for an Association Between Tako-Tsubo Cardiomyopathy and Bronchial Asthma: Retrospective Analysis in a Primary Care Hospital
Leonardo Glutz von Blotzheim1, 2, *, Stefan Christen1, Stephan Wieser3, Silvia Ulrich4, Lars C Huber3, 4
Identifiers and Pagination:Year: 2015
First Page: 1
Last Page: 4
Publisher ID: TOCMJ-9-1
Article History:Received Date: 29/11/2014
Revision Received Date: 26/1/2015
Acceptance Date: 29/1/2015
Electronic publication date: 27 /2/2015
Collection year: 2015
open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
We investigated the prevalence of bronchial asthma in patients with Tako-Tsubo Syndrome (TTS).
This retrospective case-series study was conducted in a primary care hospital in Zurich, Switzerland. Data of all patients with newly diagnosed TTS (2002 - 2012) were assessed electronically by the use of ICD-10. Asthma prevalence was compared to published epidemiologic data.
Bronchial asthma is characterized by airway inflammation and, during attack, release of endogenous catecholamines. Sympathomimetic drugs are the mainstay of treatment for asthma patients. Likewise, catecholamine mediated diffuse microvascular myocardial dysfunction seems to be of critical importance for the development of TTS.
20 cases of TTS were identified. 90% were female, showed a median age of 70±13y [25y - 90y], an apical and/or midventricular ballooning pattern with preserved basal function and a median initial LVEF of 34±9% [25% - 55%]. 65% of patients underwent coronary angiography to rule out significant coronary artery disease. Hypertension was present in 45% of patients, 35% were smokers, none was suffering from diabetes. Prevalence of asthma in patients with TTS was significantly higher compared to the normal population (25% vs. 7%, p=0.012). In 30% of the TTS patients an iatrogenic cause for development of TTS was identified.
Prevalence of asthma was significantly higher in patients with TTS compared to epidemiologic data from an age-matched population. Phenotypes of patients developing obstructive ventilatory disease and TTS might share common pathogenic mechanisms beyond the use of bronchodilatators. In addition, we identified other iatrogenic etiologies in patients with TTS.
Tako-Tsubo-Syndrome (TTS) was reported 1991 by Dote et al.  and describes the resemblance of the left ventricle during systole to Japanese octopus fishing pots. Patients with TTS present with chest pain or sudden dyspnoea, electrocardiographic changes and elevated cardiac enzymes mimicking myocardial infarction in absence of significant coronary stenosis. Transthoracic echocardiogram shows transient akinesis in the apical and/or middle ventricular segments (apical ballooning) and hyperkinesis in the basal segments of the left ventricle impairing ventricular ejection fraction  These wall-motion abnormalities usually completely resolve within days or weeks . Incidence of TTS in patients presenting with acute coronary syndromes is estimated to be around 2% [4, 5] The onset of TTS is often preceded by emotional or physical stress and the condition is, as such, also known as “broken heart syndrome” or stress-induced cardiomyopathy. However, in 30% of cases the trigger factor remains unclear . Of interest, in patients with TTS, plasma catecholamine levels have found to be several times higher as compared to patients with myocardial infarction and remained markedly elevated over a period of a week . The elevated levels of catecholamines have been associated with diffuse microvascular myocardial dysfunction and subsequent ischemia as a possible mechanism, whereas the increased adrenergic receptor density in cardiac apical segments might explain the unequal affection of the myocardium and, thus, the typical shape of affected hearts in transthoracic echocardiogram or ventriculography .
Another disease in which sympathomimetic reactions might play an important role both in pathogenesis and treatment is bronchial asthma. Bronchial asthma is a common disease with an increasing prevalence affecting about 7% of the Swiss adult population . The airway inflammation observed in bronchial asthma is, at least in part, triggered by cytokines such as IL-4, -5, and -13 , driving the eosinophilic response. The inflammatory IL-6 that appears to correlate with levels of IL-13 has been reported to be another trigger factor [10, 11]. Moreover, during an acute asthma attack, endogenous catecholamines are released .
These mediators might also be of critical importance for the development of TTS and, due to the major role of sympathomimetic drugs in the treatment of bronchial asthma as well as the release of endogenous catecholamines in exacerbations and acute asthma attacks, we assumed a higher prevalence of bronchial asthma in patients with TTS.
To address this hypothesis, a retrospective case-series study was conducted in a primary care hospital in Zurich, Switzerland. Data of all patients with newly diagnosed TTS were assessed from the hospital electronic patients database by use of the ICD-10 code. Data for several codes (e.g. I51.8, I42.8) were investigated. Upon identifying the cases of TTS, analysis for trigger factors, cardiovascular risk factors, left ventricular ejection fraction (LVEF) at time of initial diagnosis and at follow-up, results of coronary angiography and comorbidities was conducted. Patients from a period of 10 years (2002 – 2012) were included. Asthma prevalence in patients with TTS was compared to epidemiologic data for asthma in Switzerland. Statistical analysis was performed with GraphPad using non-parametric tests.
Over a period of 10 years, 20 cases of TTS were identified (details provided in Table 1). Of these cases, 90% were female, showed a median age of 70±13y [25y – 90y], an apical and/or midventricular ballooning pattern with preserved basal function and a median initial left ventricular ejection fraction of 34±9% [25% - 55%]. 65% of patients underwent coronary angiography to rule out significant atherothrombotic coronary artery disease. Hypertension was present in 45% of patients, 35% were smokers, none was suffering from diabetes. 5 of the TTS patients had been diagnosed with bronchial asthma. 3 of these had been treated with bronchodilatators only, two of which with short acting relievers. 2 patients additionally used inhaled corticosteroids. At time of hospitalization, none of the patients was under systemic corticosteroid therapy. In 2 patients, both without inhaled corticosteroids, the asthma was uncontrolled and symptomatic asthma was the reason for hospitalization. According to the patient files, the asthma was controlled in the 3 other patients. When assessed with Fisher’s exact test, the prevalence of asthma in patients with TTS was significantly higher compared to the normal population (25% vs. 7%, p=0.012). The number detected in our small inpatient cohort might even be underestimated since one patient was hospitalized with acute exacerbated chronic obstructive pulmonary disease. However, this patient was a lifelong nonsmoker and it is probable that the irreversible obstruction was due to airway remodeling from chronic asthma. Because no formal diagnosis of asthma has been mentioned in the electronic data file, this patient was not counted as having asthma.
Clinical characteristics of 20 inpatients with newly diagnosed stress induced cardiomyopathy (TTS).
As an additional finding independent of the diagnosis of asthma, in 30% of the TTS patients an iatrogenic cause for development of TTS was identified (treatment with sympathomimetic drugs in 20%; surgical procedures in 10%).
We describe here a significantly higher prevalence of asthma in patients with TTS compared to the normal population in Switzerland. These retrospectively collected, descriptive data are limited by the lack of formal controls and the low number of cases identified, the latter of which is mainly due to an allocation bias since patients presenting with acute chest pain and electrocardiographic changes compatible with ST-elevation myocardial infarction are not admitted to our clinic. Furthermore, only two thirds of patients underwent coronary angiography to rule out significant atherosclerosis which is warranted for the diagnosis of TTS according to the Mayo Clinic criteria for apical ballooning syndromem . However, since all patients without invasive diagnostic assessment showed typical echocardiographic features of TTS (i.e. transient hypokinesis, akinesis or dyskinesis of the left ventricular mid segments) and complete normalization of LVEF within the follow-up, ischemic heart disease is an unlikely cause of the observed features in this cohort of patients. Hence our results might be representative for other primary care hospitals that are lacking coronary catheterization facilities. Our data suggest that comorbidities (i.e. bronchial asthma) and iatrogenic causes (i.e. medication) might be underestimated in the inpatient setting. While complete understanding of pathogenesis of TTS is still lacking, recent data suggest catecholamine mediated diffuse microvascular myocardial dysfunction as a possible mechanism. Of interest, in patients with TTS, plasma levels of catecholamines were found to be significantly increased compared to patients with myocardial infarction and these levels remained markedly elevated over several days . In this retrospective study we have not analyzed levels of catecholamines or inflammatory cytokines. But our data suggest a potential interplay of asthma and TTS probably triggered by the use of sympathomimetic drugs and elevated levels of endogenous catecholamines. In addition, experimental data make it very likely that, next to catecholamines and betamimetic drugs, other factors could promote a final common pathway in both entities (summarized in Fig. 1). For example, in climacteric women suffering from psychological stress, the serum levels of several cytokines have been found elevated, in particular IL-6 . While postmenopausal women are prone to develop TTS, elevated levels of IL-6 interestingly were found to be increased predominantly in female asthmatic patients . IL-6 is one of the most important triggers of the acute phase response and was shown to result in aberrant expression of microRNAs [14, 15], which might also be involved in the pathogenesis of cardiomyopathies. Finally, a sustained hypereosinophilic response might be the result of eosinophilic granulomatosis with polyangiitis, which commonly presents with uncontrolled bronchial asthma. Churg Strauss vasculitis could mimic TTS, in particular with myocardial involvement. In our patients, however, we had no evidence for an “asthma-plus” syndrome such as Churg strauss vasculitis.
In conclusion, since we are not aware of any studies addressing the prevalence of bronchial asthma in inpatients with TTS, we show here first evidence of an association between these two entities. Phenotypes of patients developing obstructive ventilatory disease (in particular bronchial asthma) and TTS might share common pathogenic mechanisms beyond the use of bronchodilatators. In addition, we identified other iatrogenic – and thus preventable – etiologies in one-third of patients with TTS. The use of synthetic catecholamines, which, of note, is of controversial benefit in acute asthma , thus should be handled with caution, in particular in postmenopausal female patients that are at high risk to develop TTS.
LGVB and LCH were involved in conception, design and interpretation of data. SC, SW and SU have reviewed drafts of the article and gave final approval of the version to be published
CONFLICT OF INTEREST
The authors certify that there is no possible or actual conflict of interest regarding the material discussed in the manuscript.
This research received no grant from any funding agency in the public, commercial or not-for-profit sectors.