Incidence and Pattern of Thyroid Dysfunction in Patients on Chronic Amiodarone Therapy: Experience at a Tertiary Care Centre in Oman

H. Farhan1, A. Albulushi*, 1, A. Taqi2, A. Al-Hashim1, K. Al-Saidi1, K. Al-Rasadi3, A. Al-Mazroui1, I. Al-Zakwani4, 5
1 Department of Medicine, Sultan Qaboos University Hospital, Oman
2 Department of Pharmacy, Sultan Qaboos University Hospital, Oman
3 Department of Clinical Biochemistry, Sultan Qaboos University Hospital, Oman
4 Department of Pharmacology & Clinical Pharmacy, College of Medicine & Health Sciences, Sultan Qaboos University, Muscat, Oman
5 Gulf Health Research, Muscat, Oman

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© Farhan et al.; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the Department of Medicine, Sultan Qaboos University Hospital, PO Box: 35: post code: 123, Al-khod, Muscat, Sultanate of Oman; Tel: +968 98517982; Fax: +968 24144430; E-mail:



To determine the incidence and pattern of thyroid dysfunction (TD) in patients on chronic amiodarone therapy.


A retrospective study which evaluated 59 patients who had received amiodarone therapy regularly for at least 12 months from a period of 3 years from October 2007 to October 2010. The patients were followed-up at the cardiac clinic at Sultan Qaboos University Hospital, Muscat, Oman.


The mean age of the cohort was 63 ± 13 years ranging from 27 to 98 years. Fifty-one percent (n = 30) of the patients were female. There were 11 (19%) cases of thyroid dysfunction (TD). Seven (12%) patients were hypothyroid, 3 (5%) had hyperthyroidism and 1 (2%) patient had sub-clinical hypothyroidism; no cases of sub-clinical hyperthyroidism were noted. Female gender and presence of anti-thyroid peroxidase antibodies were significantly associated with amiodarone-induced hypothyroidism (p = 0.001) while age, amiodarone dose and duration of therapy were not correlated with the development of TD (all p-values > 0.05).


Amiodarone-induced thyroid dysfunction is prevalent. Hypothyroidism was more frequent and seen more in female patients and those who had positive anti-thyroid peroxidase antibodies. Initial screening and periodic monitoring of thyroid function is mandatory for all patients on amiodarone therapy.

Keywords: : Thyroid diseases, amiodarone, hypothyroidism, thyrotoxicosis, hyperthyroidism, Oman.