RESEARCH ARTICLE


Incidence and Pattern of Thyroid Dysfunction in Patients on Chronic Amiodarone Therapy: Experience at a Tertiary Care Centre in Oman



H. Farhan1, A. Albulushi*, 1, A. Taqi2, A. Al-Hashim1, K. Al-Saidi1, K. Al-Rasadi3, A. Al-Mazroui1, I. Al-Zakwani4, 5
1 Department of Medicine, Sultan Qaboos University Hospital, Oman
2 Department of Pharmacy, Sultan Qaboos University Hospital, Oman
3 Department of Clinical Biochemistry, Sultan Qaboos University Hospital, Oman
4 Department of Pharmacology & Clinical Pharmacy, College of Medicine & Health Sciences, Sultan Qaboos University, Muscat, Oman
5 Gulf Health Research, Muscat, Oman


Article Metrics

CrossRef Citations:
0
Total Statistics:

Full-Text HTML Views: 376
Abstract HTML Views: 764
PDF Downloads: 293
Total Views/Downloads: 1433
Unique Statistics:

Full-Text HTML Views: 257
Abstract HTML Views: 410
PDF Downloads: 193
Total Views/Downloads: 860



© Farhan et al.; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the Department of Medicine, Sultan Qaboos University Hospital, PO Box: 35: post code: 123, Al-khod, Muscat, Sultanate of Oman; Tel: +968 98517982; Fax: +968 24144430; E-mail: dr.albulushi@gmail.com


Abstract

Objective:

To determine the incidence and pattern of thyroid dysfunction (TD) in patients on chronic amiodarone therapy.

Methods:

A retrospective study which evaluated 59 patients who had received amiodarone therapy regularly for at least 12 months from a period of 3 years from October 2007 to October 2010. The patients were followed-up at the cardiac clinic at Sultan Qaboos University Hospital, Muscat, Oman.

Results:

The mean age of the cohort was 63 ± 13 years ranging from 27 to 98 years. Fifty-one percent (n = 30) of the patients were female. There were 11 (19%) cases of thyroid dysfunction (TD). Seven (12%) patients were hypothyroid, 3 (5%) had hyperthyroidism and 1 (2%) patient had sub-clinical hypothyroidism; no cases of sub-clinical hyperthyroidism were noted. Female gender and presence of anti-thyroid peroxidase antibodies were significantly associated with amiodarone-induced hypothyroidism (p = 0.001) while age, amiodarone dose and duration of therapy were not correlated with the development of TD (all p-values > 0.05).

Conclusion:

Amiodarone-induced thyroid dysfunction is prevalent. Hypothyroidism was more frequent and seen more in female patients and those who had positive anti-thyroid peroxidase antibodies. Initial screening and periodic monitoring of thyroid function is mandatory for all patients on amiodarone therapy.

Keywords: : Thyroid diseases, amiodarone, hypothyroidism, thyrotoxicosis, hyperthyroidism, Oman.