Myocardial Ischemia in Wegener’s Granulomatosis: Coronary Atherosclerosis Versus Vasculitis

Giuseppe Cocco1, *, Armen Yuri Gasparyan2
1 Cardiology Office, CH-4310 Rheinfelden, Switzerland
2 Dudley Group of Hospitals NHS Trust, West Midlands, UK

Article Metrics

CrossRef Citations:
Total Statistics:

Full-Text HTML Views: 1673
Abstract HTML Views: 559
PDF Downloads: 341
Total Views/Downloads: 2573
Unique Statistics:

Full-Text HTML Views: 866
Abstract HTML Views: 342
PDF Downloads: 252
Total Views/Downloads: 1460

Creative Commons License
© Cocco and Gasparyan; Licensee Bentham Open.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited.

* Address correspondence to this author at the Cardiology Office, POB 119, Marktgasse 10a, CH-4310 Rheinfelden, Switzerland; Tel: +004161-832-45-55; Fax: +004161-833-97-56; E-mail:


Wegener’s granulomatosis (WG) is one of the most common small- and medium-sized necrotizing vasculitides that mainly affects the upper and lower respiratory tract and the kidneys. Cardiac manifestations in WG are relatively rare, and their role and place among different causes of mortality remain largely unknown. Substantially increased number of reports describing involvement of all structures of the heart, which underlie conduction disturbances, valvular disease, ischemic heart disease and other potentially serious conditions, underscores importance of comprehensive cardiovascular investigations and monitoring of patients with WG. The majority of previous reports and our current observation distinguish coronary vasculitis and thrombosis as a cause of myocardial ischemia and cardiovascular co-morbidities in WG. It seems plausible that inflammatory processes in this disease, like in some other systemic vasculitidies, do not predispose to accelerated atherogenesis. However, characteristic small- and medium-sized vasculitis still can manifest as myocardial ischemia and infarction. We overview diverse cardiac manifestations and present our own rare case of angina in the oligosymptomatic debut of WG. Importantly, in this case, coronarography failed to reveal atherosclerotic disease or thrombotic occlusion. However, magnetic resonance imaging (MRI) with adenosine test revealed subendocardial ischemia. As a result of immunosuppressive therapy with a steroid and cyclophosphamide, myocardial ischemia disappeared.

Keywords: Wegener’s granulomatosis, Coronary arteries, Atherosclerosis, Vasculitis..