Experimental Models of Renal Disease and the Cardiovascular System
Rebecca C. Grossman*
Identifiers and Pagination:Year: 2010
First Page: 257
Last Page: 264
Publisher ID: TOCMJ-4-257
Article History:Received Date: 10/9/2010
Revision Received Date: 29/9/2010
Acceptance Date: 4/10/2010
Electronic publication date: 26/11/2010
Collection year: 2010
open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
Cardiovascular disease is a leading cause of death among patients with end stage renal failure. Animal models have played a crucial role in teasing apart the complex pathological processes involved. This review discusses the principles of using animal models, the history of their use in the study of renal hypertension, the controversies arising from experimental models of non-hypertensive uraemic cardiomyopathy and the lessons learned from these models, and highlights important areas of future research in this field, including de novo cardiomyopathy secondary to renal transplantation.