Experimental Models of Renal Disease and the Cardiovascular System

Rebecca C. Grossman*
Department of Cellular Pathology, Royal Free Hospital, London NW3 2QG, London, United Kingdom

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© Rebecca C. Grossman; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the Department of Cellular Pathology, Royal Free Hospital, Pond Street, London NW3 2QG, United Kingdom; Tel: 020 7794 0500; Fax: 020 7830 2468; E-mail:


Cardiovascular disease is a leading cause of death among patients with end stage renal failure. Animal models have played a crucial role in teasing apart the complex pathological processes involved. This review discusses the principles of using animal models, the history of their use in the study of renal hypertension, the controversies arising from experimental models of non-hypertensive uraemic cardiomyopathy and the lessons learned from these models, and highlights important areas of future research in this field, including de novo cardiomyopathy secondary to renal transplantation.

Keywords: Non-hypertensive uraemic, de novo cardiomyopathy, renal transplantation, karyotypes, isoform..