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Experimental Models of Renal Disease and the Cardiovascular System
The Open Cardiovascular Medicine Journal
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26 Nov 2010 •
RESEARCH ARTICLE
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DOI: 10.2174/1874192401004010257
Abstract
Cardiovascular disease is a leading cause of death among patients with end stage renal failure. Animal models have played a crucial role in teasing apart the complex pathological processes involved. This review discusses the principles of using animal models, the history of their use in the study of renal hypertension, the controversies arising from experimental models of non-hypertensive uraemic cardiomyopathy and the lessons learned from these models, and highlights important areas of future research in this field, including de novo cardiomyopathy secondary to renal transplantation.
Keywords: Non-hypertensive uraemic, de novo cardiomyopathy, renal transplantation, karyotypes, isoform..
