Is There an Association Between Carotid-Femoral Pulse Wave Velocity and Coronary Heart Disease in Patients with Coronary Artery Disease: A Pilot Study

Niki Katsiki1, *, Erietta Kollari1, Sotirios Dardas1, Petros Dardas2, Anna-Bettina Haidich3, Vasilios G. Athyros1, Asterios Karagiannis1
1 Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, Hip-pocration Hospital, Thessaloniki, Greece
2 Department of Cardiology, Agios Loukas Hospital, Thessaloniki, Greece
3 Department of Hygiene and Epidemiology, Medical School, Aristotle University of Thessaloniki, Greece

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© Katsiki et al.; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution-Non-Commercial 4.0 International Public License (CC BY-NC 4.0) (, which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, Hip-pocration Hospital, 49 Konstantinoupoleos 49 Str, Thessaloniki, 546 42 Greece; Tel: 0030 2310 992845; Fax: 0030 2310 835955; Email:


Arterial stiffness has been shown to predict cardiovascular morbidity and mortality. Carotid-femoral pulse wave velocity (cfPWV) is regarded the gold standard marker of arterial stiffness. In previous studies, cfPWV was associated with the presence of coronary heart disease (CHD). However, with regard to CHD severity as assessed by the Syntax Score, only brachial-ankle PWV was reported to correlate with Syntax Score; no data exist for cfPWV.

In this pilot study, we evaluated the possible associations between cfPWV, CHD and Syntax Score in 62 consecutive pa-tients (49 males; mean age: 64±12years) with chest pain undergoing scheduled coronary angiography. cfPWV was signifi-cantly higher in CHD patients than in non-CHD individuals (10 vs. 8.4 m/s; p = 0.003). No significant association was found between cfPWV and CHD severity as assessed by Syntax Score. A cut-off point of 12.3 m/s was considered as diagnostic for abnormally increased cfPWV (specificity: 97%; sensitivity: 12%; positive likelihood ratio: 3.558). Further research is needed to establish the relationship between cfPWV and Syntax Score.

Keywords: Arterial stiffness, coronary angiography, coronary heart disease, pulse wave velocity, syntax score.