Pulse Wave Analysis by Applanation Tonometry for the Measurement of Arterial Stiffness

John Doupis1, *, Nikolaos Papanas2, Alison Cohen1, Lyndsay McFarlan1, Edward Horton1
1 Joslin Diabetes Centre, Harvard Medical School, Boston, MA, USA
2 Diabetes Centre, Second Department of Internal Medicine, Democritus University of Thrace, Alexandroupolis, Greece

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© Doupis et al.; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution-Non-Commercial 4.0 International Public License (CC BY-NC 4.0) (, which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the Joslin Diabetes Centre, Harvard Medical School, Clinical Research Centre, One Joslin Place, Boston, MA, USA; Tel: 617-309-2749; E-mail:


The aim of our study was to investigate the association between pulse wave velocity (PWV) and pulse wave analysis (PWA)-derived measurements for the evaluation of arterial stiffness. A total of 20 (7 male and 13 female) healthy, non-smoking individuals, with mean age 31 ± 12years were included. PWV and PWA measurements were performed using a SphygmoCor apparatus (Atcor Medical Blood Pressure Analysis System, Sydney Australia). PWV significantly correlated with all central aortic haemodynamic parameters, especially with pulse pressure (PP) (p < 0.0001), augmentation index corrected for 75 pulses/min (AI75) (p = 0.035) and augmentation pressure (AP) (p = 0.005). Male subjects presented significantly higher PWV compared with females (p = 0.03), while there were no differences in PP, AP and AI75. In conclusion, PWA is strongly correlated with PWV as a method for the evaluation of arterial stiffness.

Keywords: Applanation tonometry, Arterial stiffness, Pulse wave analysis, Pulse wave velocity.